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dc.contributor.author | Mehtab Munir | |
dc.contributor.author | Shahid Mustafa Memon | |
dc.contributor.author | Sajid Abbas Jaffri | |
dc.contributor.author | Khalid Mustafa Memon | |
dc.date.accessioned | 2020-02-12T10:36:21Z | |
dc.date.available | 2020-02-12T10:36:21Z | |
dc.date.issued | 2019-10-01 | |
dc.identifier.issn | 2220-7562 | |
dc.identifier.uri | http://hdl.handle.net/123456789/9246 | |
dc.description.abstract | Objective: To compare clinical efficacy of diacerein-ginger with diacerein alone in treating knee osteoarthritis. Duration and place of study: It was a randomized clinical trial conducted from 21st September 2018 to 31stMarch 2019, in medical OPD of a private hospital in Karachi. Methodology: 60 diagnosed patients of knee osteoarthritis were included in this study. Male and female patients 50 years of age, fulfilling the inclusion criteria and after written informed consent experienced a wash-out period of 72 hours. These patients were systematically randomized into 2 groups each having 30 members. Group A received capsule Diacerein 50mg + capsule Ginger 550 mg twice daily and group B received capsule Diacerein 50mg twice daily, for 12 weeks. Parameters checked at 0, 6 and 12 weeks were: Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index, pain at rest and movement (Visual Analogue Scale). Comparison of the two groups was done by independent t-test. Results: Among 60 patients; 20 (33.33 %) were males and 40 (66.66%) were females. 4 patients in group A and 4 in B, dropped out during the study. Comparison of group A with group B in WOMAC and pain (at rest and movement) scores showed insignificant difference at day 0 before prescription of the drugs. However comparison showed highly significant difference (P-value < 0.001) between the two groups in WOMAC, pain at rest and movement scores at the end of 6th and 12th weeks of intervention. Conclusion: Diacerein-Ginger is clinically more efficacious for management of knee OA than Diacerein alone | en_US |
dc.description.sponsorship | JBUMDC | en_US |
dc.language.iso | en | en_US |
dc.publisher | Bahria University Medical and Dental College Karachi | en_US |
dc.relation.ispartofseries | 9;4 | |
dc.subject | knee, osteoarthritis, ginger, diacerein, WOMAC score, pain score | en_US |
dc.title | Comparison Of Diacerein-Ginger With Diacerein Alone In Treating Knee Osteoarthritis | en_US |
dc.type | Article | en_US |