Relationship of Age, BMI, Serum Calcium and Estradiol with BMD in Postmenopausal Osteoporotic Females

Abstract

Introduction: The current study was designed to investigate the relationship of age, body mass index (BMI), serum calcium and estradiol with bone mineral density (BMD) in postmenopausal females with and without osteoporosis. Subjects & Methods: One hundred females were included in this study and were divided into two groups (fifty in each group): postmenopausal females without osteoporosis (age: 54.36 ± 0.51 yrs) and postmenopausal females with osteoporosis (age: 59.92 ± 0.68 yrs). BMD assessment was done on calcaneous by peripheral ultrasound bone densitometry and T scores were calculated. Serum estradiol was measured by ELIZA and calcium levels were determined by using spectrophotometric kit. Results: BMD was significantly lower in postmenopausal osteoporotic females as compared to postmenopausal non-osteoporotic females which indicated increased bone loss in osteoporotic group. Serum calcium levels were significantly lower in postmenopausal females with osteoporosis (8.73 ± 0.08) as compared to postmenopausal females without osteoporosis (9.04 ± 0.09). BMD was correlated with body weight ( r= 0.50, p<0.05; r= 0.45, p<0.05) and BMI (r=0.61, p<0.01; r= 0.31, p<0.05) in both groups. Negative correlation of BMD was found with age (r= -0.67, p<0.01r= -0.57, p<0.05) and calcium (r= -0.44, p<0.05; r= -0.38, p<0.05) in postmenopausal females with and without osteoporosis respectively. Osteopenia was detected in postmenopausal females without osteoporosis. Conclusion: It is concluded that increasing age, low body weight, low BMI, and low BMD are few of the contributing factors to osteoporosis.