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dc.contributor.author | Nasim Karim | |
dc.contributor.author | Khalid Mustafa | |
dc.contributor.author | Talea Hoor | |
dc.contributor.author | Riffat Farooqui | |
dc.date.accessioned | 2018-12-05T10:35:04Z | |
dc.date.available | 2018-12-05T10:35:04Z | |
dc.date.issued | 2012-01-01 | |
dc.identifier.issn | 2220-7562 | |
dc.identifier.uri | http://hdl.handle.net/123456789/7884 | |
dc.description.abstract | Objective: To compare the effects of metformin with diet & exercise on ovulation & menstrual regularity in PCOS infertile women . Study Design: Randomized clinical trial. Place & Duration of study: Private hospital infertility clinic at Karachi from 2001-2004. Patients & Methods: One hundred & eleven PCOS women with primary infertility were enrolled. and divided into group A & B with 57 & 54 patients respectively. Group A received tablet metformin 500mg thrice daily along with diet & exercise advice while group B was kept on diet & exercise alone (30-60 minutes walk daily & avoidance of oily foods, red meat & bakery products) for a period of 90 days. Menstrual regularity & plasma progesterone level were evaluated at day-0 and day-90. Fasting serum glucose, insulin, follicle stimulating hormone, luteinizing hormone, prolactin, testosterone & ultrasound pelvis were done at day- 0 for diagnosis of PCOS. Results: 100 patients completed the study. 50 patients in each group.In group A, 44 (88%) patients developed regular cycles with statistically significant increase in serum progesterone whereas in group B only 3(6%) patients developed regular cycles with non-significant increase in serum progesterone level from day-0 to day-90. Group A showed ovulation in 82% patients in comparison to Group B where ovulation occurred in only 6% of patients. Conclusion: Metformin produced beneficial effects in comparison to diet & exercise alone in PCOS infertile women. | en_US |
dc.description.sponsorship | JBUMDC | en_US |
dc.language.iso | en | en_US |
dc.publisher | Bahria University Medical and Dental College Karachi | en_US |
dc.relation.ispartofseries | 2;1 | |
dc.subject | Polycystic ovary syndrome , Metformin, Diet & exercise, Menstrual regularity, Ovulation. | en_US |
dc.title | Effect of Metformin Versus Diet and Exercise on Ovulation & Menstrual Regularity in PCOS | en_US |
dc.type | Article | en_US |