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dc.contributor.author | Obaid Anwar | |
dc.contributor.author | Mazhar Iqbal | |
dc.contributor.author | Sadia Chiragh | |
dc.contributor.author | Owais bin Qadeer Gill | |
dc.contributor.author | Muhammad Iqbal | |
dc.date.accessioned | 2018-11-12T08:10:37Z | |
dc.date.available | 2018-11-12T08:10:37Z | |
dc.date.issued | 2018-10-01 | |
dc.identifier.issn | 2220-7562 | |
dc.identifier.uri | http://hdl.handle.net/123456789/7681 | |
dc.description.abstract | Objectives: To investigate hepato-protective effect of ethanolic leave extract of Raphanus sativus against atorvastatin induced hepatotoxicity in albino rabbits. Study design: Experimental study Material and Method: This study conducted at department of Physiology and Pharmacology, University of Agriculture, Faisalabad. The ethanolic extract of Raphanus sativus was prepared for hepatoprotective effect against hepatotoxicity produced by atorvastatin. Results: The results were compared with normal and experimental control. Serum was tested for ALT, AST, Alkaline Phosphatase and Bilirubin along with histological studies. Ethanolic extract of Raphanus sativus with 100mg/kg. of body weight dosage developed some changes representing hepatotoxicity but higher doses showed an increase in toxicity as observed on histologic sections. A reduction in fibrosis and cholestasis was observed which needs further evaluation. Conclusion: Ethanolic extract of raphanus sativus did not show any amelioration in the increased enzymes level however a reduction in cholestasis was observed as represented by decreases in alkaline phosphatase levels also confirmed by histological studies | en_US |
dc.description.sponsorship | JBUMDC | en_US |
dc.language.iso | en | en_US |
dc.publisher | Bahria University Medical and Dental College Karachi | en_US |
dc.relation.ispartofseries | 8;4 | |
dc.subject | ALT, AST, Alkaline phosphatase, Bilirubin, Atorvastatin, Raphanus sativus | en_US |
dc.title | Effect of Raphanus Sativus (Radish) Leaf Extract on Atorvastatin Induced Hepatotoxicity in Rabbits | en_US |
dc.type | Article | en_US |