Abstract:
Objective: To determine the outcome of wilms tumors among children in our center and compare the results of treatment
on the basis of management proposed by the National Wilms tumor study board (NWTS) and the Societe international
D’oncologie pediatrique (SIOP)
Patients and methods:- This study includes 49 children who presented to the Aga Khan University Hospital(AKUH) with
wilms tumors from January 1988 to December 2015 (aged 0-16 years). Patients were further divided according to the
treatment strategies they received i.e NWTS and SIOP. Data was analyzed using SPSS 10.
Results:-.A total of 49 patients (57%male and 43% female) were included in the study. Majority of the cases (56%) were
between 1-5 years. The tumors mostly presented on the right side (65%).The diagnostic work up of the patients mainly
involved CT imaging (69%).35% of children in the SIOP group presented with stage 3 diseases whereas in the NWTS
group 42% presented with stage 1 disease. In the SIOP group 4 (14%) patients had disease reoccurrence and 2 (7%) patients
died. In the NWTS group 2(10%) patients had disease reoccurrence and 1 (5%) patient expired. A 5 year survival rate of
both groups was calculated to be more than 80%. Mean follow up in SIOP group was 119 months and In NWTS group
was 114 months.
Conclusions:- Wilms tumors are curable in the majority of the patients even with limited resource as in our country. The
NWTS and SIOP treatment approaches are almost equally effective at our center however adherence to a single treatment
is mandatory for effective treatments
