Correlation Of Serum YKL-40 With Anthropometric Measurements And Spirometric Indices Between Healthy Individuals And Asthamatics In A Tertiary Care Hospital

Abstract

To correlate serum levels of YKL-40 with anthropometric measurements and spirometric indices between normal individuals and asthmatics. Methodology: The case control study was conducted in Department of Chest Medicine, JPMC, Karachi from the month of August 2015 till March 2016. The study recruited sixty participants after satisfying the inclusion and exclusion criteria; among those 30 were normal healthy individuals (PEF > 80% and pulse rate of 60 – 80 beats per minutes); while equal were cases of mild to moderate asthma (PEF more than 50% and pulse rate of 100 – 120 beats per minutes) matched for age and gender. Vitallograph compacta and peak flow meter was used for spirometric indices. Moreover, anthropometric measurements were age, gender, weight (kg), height (m) and body mass index (kg/m2). Ykl-40 Elisa kit was used for serum YKL 40 levels. The data was entered and analysed using SPSS version 21 (IBM, Chicago, IL). Result: In comparison of Spirometric Evaluation (FEV1, FVC, FEV1/FVC% and PEFR) between control and patients with mild to moderate asthma. significant difference was found in the mean values of FEV1, FVC, FEV1/FVC and PEFR between cases and controls. Significant inverse correlation was found between YKL-40 with FEV1, FVC, FEVI/FVC% and PEFR among Controls. YKL-40 was found to be significantly correlated with only FEV1/ FVC (%) among cases with correlation co-efficient as – 0.510 (p-value < 0.004). Conclusion: There is an inverse correlation between serum YKL-40 levels and spirometric evaluation thus as the inflammation in asthma increases, YKL-40 level upsurges and causes decrease in lung function tests