Abstract:
Background: For a long time, Diabetes mellitus has been treated with medicines derived from plants.
Objective: To evaluate the effect of Ginger aqueous extract on Glomerular mesangial matrix in Alloxan induced diabetic
nephropathy of albino rats.
Materials and Methods: In this study we induced diabetes mellitus with Alloxan intraperitoneally (150 mg/kg body
weight) in Experimental groups B & C. Then the rats of Experimental group C received 200mg/kg body weight of ginger
aqueous extract by gavage daily for five weeks starting from 8th day after Alloxan injection.
Results: We observed that on histopathological examination, Experimental group B kidneys revealed highly increased
mesangial matrix while the animals of experimental group C treated with ginger aqueous extract showed less increase in
mesangial matrix as compared to experimental group B but it was more than control group A. Three groups had significant
difference among them having p-values <0.001.
Conclusion: The results of the present study indicated that the co-treatment of Ginger aqueous extract prevented alloxan
induced diabetic nephropathy in albino rats. The aqueous extract of Ginger showed amazing results regarding renal
histopathology of diabetic rats. The overall nephroprotective effect of Ginger is probably due to a counteraction of free
radicals by its antioxidant components.
