Abstract:
Objective: To investigate the thyroid function, C-reactive protein (CRP) and blood lipid profile in the subclinical
hypothyroidism (SH) patients in surgical wards and outpatient department.
Study design: Cross sectional study
Place and Duration: Department of surgery, Isra University Hospital from August 2014 to May 2017.
Materials and Methods: 100 subclinical hypothyroid cases and 100 controls were included according to inclusion
and exclusion criteria. Serum TSH level > 6.2 (μIU /ml) with normal free T4 and T3 was considered as subclinical
hypothyroidism. Venous blood was taken from ante cubital vein, centrifuged and processed. Sera were used for the
assay of thyroid hormones, TSH, blood lipids and C-reactive protein. Data variables were analyzed by Statistix 8.0
(95% confidence interval) (P-value =0.05).
Results: Age in controls and cases was noted as 51.3±12.5 and 50.8±11.95 years respectively. SH cases show serum
T3, T4 and TSH as 0.89±0.18 μg/dl, 4.96±0.85 μg/dl and 11.95±2.85 μU/ml respectively. Serum total cholesterol,
triglycerides and LDLc were raised with concomitant low HDLc in SH cases. C- reactive protein in SH cases was
6.91±3.38 ng/ml compared to controls 2.56±1.51 ng/ml (P=0.0001). Serum TSH showed negative correlation with
HDLc, serum T3 and T4.
Conclusion: The present study reports dyslipidemia with elevated inflammatory marker of C-reactive protein in
subclinical hypothyroid patients.
