Abstract:
Objective: This study provides histological evidence of the combined effects of L-Carnitine, and Coenzyme Q10 on
gliosis and anhedonia in a rat model of multiple sclerosis (MS).
Methods: Fifty male Sprague Dawley rats were randomly divided into 5 groups of 10 rats each. Group 1 was the
control group. The rest of the groups were disease models and were given 0.2% cuprizone w/w to induce MS. After
4 weeks, Group 3 started receiving L-Carnitine, Group 4 was given Coenzyme Q10, and Group 5 received both, while
cuprizone poisoning continued. After 12 weeks sucrose preference test and tail suspension test were performed for
anhedonia. Rats were euthanized and brains were dissected, and assessed for astrocytes, oligodendrocytes, and microglial
count.
Results: A significant increase in oligodendrocyte count, while a reduction in astrocyte and microglial count was seen
in the synergistic group (p ＜ 0.05). Synergism could not be proved in anhedonia.
Conclusion: The combination of Coenzyme Q10 and L-Carnitine has a synergistic effect in controlling gliosis in a rat
model of MS, but synergism could not be demonstrated on anhedonia.
