Heamatological and biochemical parameters with different serological status in dengue patients.

Abstract

Objective: To compare the hematological and biochemical parameters of dengue patients within different serological markers. Study Design: Cross Sectional study. Setting: Carried out in a Tertiary Care Hospital at Rawalpindi. Period: August 2023 to December 2023. Methods: Of 250 seropositive dengue cases Hematological analysis was done by Mindray 3000 plus. For biochemical analysis Beckman &coulter, AU480 was used. Subjects were distributed into seven serogroups (NS1 positive, NS1+IgG, NS1+IgM positive, IgM positive, IgG positive, IgG+IgM, NS1, IgM+IgG and triple positive). Results were analyzed using SPSS software, ANOVA test was used, and means were compared in different groups. P value of <0.05 was considered as significant. Results: A total of 178 (71%) among study group were male. Mean age was found to be 37±13.8 years. NS1 antigen either in isolation or in combination was positive in 80%of patient at the time of presentation. The most affected parameters among the whole study cohort were low mean platelet count (81.90±49.2) and higher mean value of ALT (92.81±75.07). The mean value of haematological and biochemical parameters were studied in different serological groups. No significant difference of mean haemoglobin and platelet was observed in between different serological groups however Mean TLC differ significantly within these subgroups (p value = <0.05). The Mean values of various biochemical parameters did not exhibit any significant difference within the different serological groups. Conclusion: Dengue is more prevalent in young population and in males. Thrombocytopenia and elevated ALT levels were most common laboratory finding observed in these patients. NS1 was the most frequent marker at the time of presentation. Only Mean TLC (p value = <0.05) was observed to be significantly different in between different serological groups.