Abstract:
OBJECTIVE: To determine the reference values of PT and APTT amongst the healthy infants of < 1 year of
age.
SUBJECTS AND METHODS: It was a descriptive cross sectional study carried out at Haematology
department of Armed Forces Institute of Pathology (AFIP), Rawalpindi. The Study duration was1 year and
Non-probability convenience sampling was adopted for 2000 blood samples.
The Sampling areas were MH, CMH, HFH and SBBH, Rawalpindi.The Data analysis was done by SPSS
version 15. Mean, SD and percentages were the quantitative and qualitative variables used for statistical
analysis.
The PT value for clot formation was detected by the addition of thromboplastin reagent to plasma sample.
While APTT value for clot formation was extracted by the addition of equal volume of phospholipid reagent
and Kaolin suspension.
RESULTS: The mean PT value amongst males and female uptil 9 month of age has shown no significant
difference. While at age 1year females have higher PT values i.e 15.13 sec. (SD=2.25) when compared to
males i.e 14.22 sec. (SD=0.63). However qualitative analysis has shown that 12- 15sec.was the frequently
observed range in 95.15% (n=1903) infants. The mean APTT value was found to have same mean values
for males and females. However, qualitative analysis has shown that 32-35 sec was the frequently observed
range in 85% (n=1700) infants.
CONCLUSION: The mean values of PT and APTT are almost same when compared to the adult values.
They are not affected by the growing ages of an infant.
