Abstract:
Rheumatic fever (RF) and Rheumatic Heart Disease (RHD) continues to be a global health problem since
long. Moreover, it is a leading cause of morbidity and mortality especially in younger age group i.e. 3–18
years.
RF is a non suppurative complication of Group A Streptococcus Pyogenes (GASP) pharyngeal infection
observed in post streptococcus sequelae. The reason for this is the negligence of diagnosis and improper
treatment. While if diagnosed early and treated well within 10 days of onset of pharyngitis, occurrence of this
life threatening condition can be prevented.
Apart from many virulent factors produced by GASP, the most important ones for the pathogenesis are the M
proteins i.e. antigens and the Streptolysin O. Only M proteins of GASP have the strong rheumatogenic
potential while the rises in Streptolysin O titer levels are suggestive of recent GASP pharyngeal infection.
The significant level of ASO titer is >200.
The current review article will provide update information regarding early diagnosis of GASP pharyngeal
infection by ASO titers in different ages. Thus, by initiating early treatment, the morbidity and mortality rates
due to RF and RHD can be reduced in under developed countries like ours.
