Abstract:
Primary hepatic lymphoma (PHL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL). A 55-year-old
male patient presented to us with jaundice and right upper quadrant pain. Investigations showed elevated
alkaline phosphatase, lactate dehydrogenase, total bilirubin, normal alanine transaminase, and negative
viral profile. Sonographic and computed tomographic scans show hepatosplenomegaly with hypodense
lesion in liver associated with lymph nodes enlargement in the region of porta hepatis celiac axis,
mediastinal and axillary lymphadenopathy. On immunohistochemistry, cells were positive for cluster of
differentiation (CD)-19, CD-20, CD-21, c-myelocytomatosis oncogene (c-MYC), B-cell lymphoma 2 (Bcl-2),
multiple myeloma oncogene-1 (MUM-1), same as B cell markers so it is diagnosed as PHL. DLBCL especially
PHL shall be considered among the differentials of space-occupying lesions of liver. Early diagnosis of
primary hepatic lymphoma is not a difficult task if excisional lymph node biopsy is taken following detection
on ultrasound or CT scan which will lead to improved treatment, improvement in survival, and costeffectiveness
with good prognostic outcomes.
Categories: Internal Medicine, Pathology, Oncology
