Mitochondrial tRNAleu(UUR) gene A3245G Mutation in Type 2 Diabetes

Abstract

A dwarfish thief today, diabetes, is a hazard that troubles the society, thriving every single moment. The time is not far away when it arises as a wicked giant, seizing the world in the deadly grasps and becoming a severe challenge for physicians everywhere. Diabetes Mellitus (DM), a commonly occurring, multifactorial disorder, has affected around 10% of the population in Western countries and Japan. The pandemic frequency of DM is continuously cropping up. Increased prevalence of DM has been observed in Asian region. As per one report published in 2013, 36 % of diabetic population is from Asian countries. This increased occurrence in Asian population can be attributed to increasing incidence of more body weight, sedentary life style, genetic or other environmental factors including poverty. In such countries death rate is higher in diabetics due to overwhelming diabetic complications like infections and cardiovascular pathologies. In past few decades, clinical features of the diabetic patients were analyzed and a new trend of lower body mass index and early onset of Type 2 diabetes mellitus (T2D)was observed. The involvement of molecular element in the development of T2D in younger age group remains focus of research for many years and is yet to be explored fully.