Anthropometric Parameters in Polycystic Infertile Women Treated with Metformin

Abstract

Background: To assess the effectiveness of Metformin in correcting anthropometric parameters in infertile women with polycystic ovary syndrome. Methods: One hundred and seventy women in Group A and 145 in Group B fulfilling the clinical and biochemical criteria for PCOS were enrolled. Group allocation was done by randomization. Metformin was started at an oral dose of 500mg/day and maintained at 1500mg/ day for 3 months in Group A and 6 months in Group B. Anthropometric parameters such as waist to hip ratio, subscapularis skin fold thickness and BMI (Body Mass Index) were calculated before the start of treatment and after treatment with metformin. Results: Patients were subjected by consecutive sampling in the randomised controlled trial.In Group A and B waist to hip ratio, subscapularis skin fold thickness and body mass index (BMI) decreased highly significantly (p=0.000) after treatment with Metformin for three and six months respectively. When comparison of differences of parameters was done from baseline to after treatment values significant difference was found in Group B (p=0.000) in waist to hip ratio and subscapularis skin fold thickness. The difference of BMI showed no significant change Conclusion:Three and six months treatment with Metformin results in decrease in parameters such as waist to hip ratio, subscapularis skin fold thickness and BMI.Six months treatment with Metformin is more beneficial as compared to three months treatment as it results in more improvement of anthropometric parameters which were deranged in polycystic infertile patients.