Abstract:
Background: To assess the effectiveness of
Metformin in correcting anthropometric parameters
in infertile women with polycystic ovary syndrome.
Methods: One hundred and seventy women in
Group A and 145 in Group B fulfilling the clinical
and biochemical criteria for PCOS were enrolled.
Group allocation was done by randomization.
Metformin was started at an oral dose of 500mg/day
and maintained at 1500mg/ day for 3 months in
Group A and 6 months in Group B. Anthropometric
parameters such as waist to hip ratio, subscapularis
skin fold thickness and BMI (Body Mass Index) were
calculated before the start of treatment and after
treatment with metformin.
Results: Patients were subjected by consecutive
sampling in the randomised controlled trial.In
Group A and B waist to hip ratio, subscapularis skin
fold thickness and body mass index (BMI) decreased
highly significantly (p=0.000) after treatment with
Metformin for three and six months respectively.
When comparison of differences of parameters was
done from baseline to after treatment values
significant difference was found in Group B
(p=0.000) in waist to hip ratio and subscapularis skin
fold thickness. The difference of BMI showed no
significant change
Conclusion:Three and six months treatment with
Metformin results in decrease in parameters such as
waist to hip ratio, subscapularis skin fold thickness
and BMI.Six months treatment with Metformin is
more beneficial as compared to three months
treatment as it results in more improvement of
anthropometric parameters which were deranged in
polycystic infertile patients.
