Abstract:
Background: Along with other advantageous effects nuts are good for fertility and can improve
derangements in different fertility parameters. With increasing incidence of hypertension leading to an
increase in consumption of antihypertensives it is inevitable to depart their side effects. This study was
designed to see the effect of administration of Prunus amygdalus, atenolol and combination of atenolol
and Prunus amygdalus on level of serum luteinizing hormone (LH) in male Balb-C mice. Methods: It
was an animal experimental study conducted in Physiology Department, Shifa College of Medicine,
Islamabad, in collaboration with Shifa International Hospital, Islamabad, National Institute of Health,
Islamabad and Centre for Research in Experimental and Applied Medicine (CREAM) Lab, Army
Medical College, Rawalpindi from December 2013 to June 2014. After approval from Ethical Review
Board, 120 mice which fulfilling inclusion criteria were divided into 4 groups of 30 mice each. Group
A served as control group, group B mice were given atenolol, group C mice were given extract of
almonds and group D mice were given atenolol and almonds. After the completion of 3 months, blood
sampling was done and serum LH was measured. Data was analyzed on SPSS-17, Mean±SD was
calculated for luteinizing hormone levels. One-way ANOVA was applied and p≤0.05 was considered
significant. Results: The mean value of serum LH in group B (Atenolol treated) was found to be
significantly elevated. In group C (Almonds) serum LH was decreased but not significantly. Mean
serum LH level in group D (Atenolol+Almond) was raised as compared to control group, but not
significantly. Conclusion: Administration of Prunus amygdalis does not affect serum LH but atenolol
causes a rise in serum LH.
