Abstract:
Objective: To study the protective effect of olive oil against histological changes induced by arsenic in liver of
albino rats.
Study Design: Randomized control trail.
st th Place and Duration of Study: The research was carried out from 1 to 30 November 2017 at National institute
of Health, Islamabad.
Materials and Methods: Forty five male adult albino rats were placed in three cages having 15 rats each.
Distilled water was given to rats of control group I for 30 days. The rats of group II were given 40mg per kg per
day of Sodium Arsenite dissolved in drinking water for 30 days. Rats in group III, in addition to sodium Arsenite
received olive oil, 0.2ml per day for 30 days along with Sodium Arsenite. Dissection was done after 30 days and
liver was dissected out for histological changes.
Results: The use of olive oil improved the gross and microscopic changes induced by Arsenic in liver lobes(right
lateral and left lateral) of Albino rats of group III as compared to group II rats, which received only arsenic.
Among microscopic parameters, sinusoidal dilation, pyknosis and necrosis was markedly reduced by use of
olive oil in group III rats whereas hemorrhage was absent in group III.
Conclusion: Olive oil protects histological changes caused by arsenic in liver of Albino rats which include
sinusoidal dilation, congestion, pyknosis, necrosis and haemorrhage.
