• Heamatological and biochemical parameters with different serological status in dengue patients. 

  Huma Amin, Shameela Majeed, Wafa Omer, Shumaila Najeeb, Nadia Wali, Fatima tuz Zuhra (The Professional Medical Journal, 2025)

  Objective: To compare the hematological and biochemical parameters of dengue patients within different serological markers. Study Design: Cross Sectional study. Setting: Carried out in a Tertiary Care Hospital at ...
• Pathogenic nsSNPs of protein kinase C-eta with hepatocellular carcinoma susceptibility 

  Tayyaba Hussain1, Yasmin Badshah1*, Maria Shabbir1, Fizzah Abid1, Ghulam Murtaza Kamal1, Amna Fayyaz1, Janeen H. Trembley, Tayyaba Afsar, Fohad Mabood Husain and Suhail Razak (Cancer Cell International, 2024)

  Background Hepatocellular carcinoma (HCC) is a global health concern. Due to late diagnosis and limited therapeutic strategies, HCC based mortality rate is exponentially increasing globally. Genetic predisposition is ...
• Non‑synonymous SNPs variants of PRKCG and its association with oncogenes predispose to hepatocellular carcinoma 

  Fizzah Abid, Khushbukhat Khan, Yasmin Badshah, Naeem Mahmood Ashraf, Maria Shabbir, Arslan Hamid, Tayyaba Afsar, Ali Almajwal and Suhail Razak (Cancer Cell International, 2023)

  Background PRKCG encodes PKC γ, which is categorized under the classical protein kinase C family. No studies have specifically established the relationship between PRKCG nsSNPs with structural and functional variations ...
• Investigating the pathogenic potential of PKC-eta UTR variants in cancer progression 

  Tayyaba Hussain, Yasmin Badshah, Maria Shabbir, Fizzah Abid , Dilawar Khan, Janeen H. Trembley, Tayyaba Afsar, Ali Almajwal, Suhail Razak (Computers in Biology and Medicine, 2025)

  A single-nucleotide polymorphism (SNP) is a naturally occurring variation in genomic DNA. Untranslated regions (UTRs) are involved in the regulatory pathways of cells that influence transcriptional and translational ...
• Inherited metabolic disorders: presentation, clinical types, laboratory diagnosis and genetic markers 

  Aamir Ijaz, Seyyedha Abbas, Maria Shabbir, Yasmin Badshah, Fizzah Abid, Tayyaba Afsar and Suhail Razak (Orphanet Journal of Rare Diseases, 2025)

  Inherited metabolic disorders (IMDs) are classified under rare genetic diseases almost always presenting in newborn and infants. IMDs are classified according to the clinical presentation, diagnosis and prognosis. Several ...
• Genetic Variants at PRKCG Splice and UTR Sites Promote Cancer Susceptibility by Disrupting Epigenetic and miRNA Regulatory Network 

  Fizzah Abid, Khushbukhat Khan, Naeem Mahmood Ashraf, Yasmin Badshah, Maria Shabbir, Janeen H Trembley, Tayyaba Afsar, Ali Almajwal, Suhail Razak (Journal of Cancer, 2024)

  The changes in the protein kinase C gamma gene (PRKCG) expression are associated with both coding and non-coding variants. No studies have specifically established the association between PRKCG 3′UTR, 5′UTR, donor and ...
• Genetic polymorphism in untranslated regions of PRKCZ influences mRNA structure, stability and binding sites 

  Aneela Mustafa, Maria Shabbir, Yasmin Badshah, Khushbukhat Khan, Fizzah Abid, Janeen H. Trembley, Tayyaba Afsar, Ali Almajwal and Suhail Razak (BMC Cancer, 2024)

  Background Variations in untranslated regions (UTR) alter regulatory pathways impacting phenotype, disease onset, and course of disease. Protein kinase C Zeta (PRKCZ), a serine-threonine kinase, is implicated in ...
• Analyzing PKC Gamma (+ 19,506 A/G) polymorphism as a promising genetic marker for HCV‑induced hepatocellular carcinoma 

  Fizzah Abid, Talha Iqbal, Khushbukhat Khan, Yasmin Badshah, Janeen H Trembley, Naeem Mahmood Ashraf, Maria Shabbir, Tayyaba Afsar, Ali Almajwal and Suhail Razak (Biomarker Research, 2022)

  Background: HCC is a major health concern worldwide. PKC gamma, a member of the conventional PKC subclass, is involved in many cancer types, but the protein has received little attention in the context of single ...
• Association of Monoamine Oxidase A Gene Promoter Region (30 bp μVNTR) Polymorphism with Serum Levels in Multiple Psychiatric Disorders 

  Aisha Nasir Hashmi 1, Rizwan Taj 2, Zehra Agha 1,3, Raheel Qamar , Jamal B. Williams , and Maleeha Azam (Biomedicines, 2025)

  Background: Monoamine oxidase A (MAOA) has a role in metabolising different biogenic amines, including dopamine. Functional studies have revealed the effect of promoter region variants on the transcriptional activity of ...
• Association of 11 variants of the dopaminergic and cognitive pathways genes with major depression, schizophrenia and bipolar disorder in the Pakistani population 

  Aisha Nasir Hashmi, Merlyn Sabina Raja, Rizwan Taj, Raees Ahmed Dharejo, Zehra Agha, Raheel Qamar & Maleeha Azam (International Journal of Neuroscience, 2023)

  Background: The dopaminergic pathways control neural signals that modulate mood and behaviour along and have a vital role in the aetiology of major depression (MDD), schizophrenia (SHZ) and bipolar disorder (BD). Genome-wide ...
• Contributing risk factors of common psychiatric disorders in the Pakistani population 

  Aisha Nasir Hashmi · Raheel Qamar · Rizwan Taj · Usama Bin Zubair · Zehra Agha · Saddam Akber Abbasi· Maleeha Azam (European Archives of Psychiatry and Clinical Neuroscience, 2023)

  With an increasing incidence of psychiatric disorders worldwide, there is a need for a better understanding of the populationspecific contributing risk factors that are associated with common psychiatric conditions. This ...
• Association of dopamine β-hydroxylase polymorphism rs1611115 and serum levels with psychiatric disorders in Pakistani population 

  Aisha Nasir Hashmi, Raees Ahmed Dharejo, Usama Bin Zubair, Netasha Khan, Iqra Kashif, Muhammad Ajmal, Rizwan Taj, Raheel Qamar & Maleeha Azam (International Journal of Neuroscience, 2022)

  Aim: Dopamine β-hydroxylase (DBH) is a copper-containing enzyme that has an important role in maintaining the cellular homeostasis between the two neurotransmitters, dopamine (DA) and nor-adrenaline (NA). DBH functional ...
• Genetic Association of Butyrylcholinesterase with Major Depressive Disorder 

  Sliha Awan · Aisha N. Hashmi · Rizwan Taj · Sadaf Munir · Rabia Habib · Sajida Batool · Maleeha Azam · Raheel Qamar · Syed M. Nurulain (Biochemical Genetics, 2021)

  Major depressive disorder (MDD) is characterized as clinical depression, which primarily affects the mood and behaviour of an individual. In the present study butyrylcholinesterase (BChE), a co-regulatory cholinergic ...
• Synthetic β‑hydroxy ketone derivative inhibits cholinesterases, rescues oxidative stress and ameliorates cognitive deficits in 5XFAD mice model of AD 

  Syed Ilyas Ahmad · Gowhar Ali · Tahir Muhammad · Rahim Ullah · Muhammad Naveed Umar · Aisha Nasir Hashmi (Molecular Biology Reports, 2020)

  Alzheimer’s disease (AD) is a progressive, chronic and age-related neurodegenerative disorder that affects millions of people across the world. In pursuit of new anti-AD remedies, 2-[Hydroxy-(4-nitrophenyl)methyl]-cyclopentanone ...
• Pharmacological effects of Ibuprofen on learning and memory, Muscarinic receptors genes expression and APP isoforms levels in Prefrontal cortex of AlCl3induced toxicity mouse model 

  Aisha Nasir Hashmi, Ahmed Yaqinuddin, Touqeer Ahmed (International Journal of Neuroscience, 2014)

  Aluminium metal (Al) has been implicated in etiology of many neurodegenerative diseases, most commonly the Alzheimer’s disease (AD). Al causes the biochemical defects, by affecting the neurotransmitters levels, causes ...
• Heamatological and biochemical parameters with different serological status in dengue patients. 

  Huma Amin, Shameela Majeed, Wafa Omer, Shumaila Najeeb, Nadia Wali, Fatima tuz Zuhra (The Professional Medical Journal, 2025)

  Objective: To compare the hematological and biochemical parameters of dengue patients within different serological markers. Study Design: Cross Sectional study. Setting: Carried out in a Tertiary Care Hospital ...
• Influence of open-top chambers induced climate warming on secondary metabolic profile of culturally and medicinally important plants of Himalaya, Karakoram and Hindukush 

  Saira Karimi, Muhammad Ali Nawaz, Saadia Naseem, Zahid Ali (PLOS One, 2025-05-14)

  Plants native to colder climates, higher elevations, or semi-arid regions have more phenolic compounds in their organs. Faced with the current climate crisis, the effects of global heating with overgrazing pressure on ...
• Vector-Born Diseases in The Warming World, Imperative for Interdisciplinary Collaboration 

  Saira Karimi, Wafa Omer (Journal of Nursing and Allied Health, 2024)
• RNA isolation efficacy of commercial and modified conventional methods for Citrus tristeza virus and mRNA internal control amplification 

  Nesheman Huma, Shagufta Sahar; Yasir Iftikhar, Abid Azhar; Saddia Galani (Biologia, 2020-01-08)

  High quality RNA is critical for molecular and viral diagnostic applications. In case of citrus, polyphenol and polysaccharide rich content hinders many RNA isolation methods causing low quality RNA. These shortcomings ...
• Cloning of Brazzein Gene (Sweet Protein) Into Pbi121 Vector Through Prokaryotic Expression System 

  B. Saleh, N. Huma; S. Galani (Journal of Animal & Plant Sciences, 2023-06-18)

  Brazzein- a low-calorie natural sweetener is an effective substitute for deleterious effects of sucrose. Uptill now, limited production of recombinant brazzein protein using heterologous expression system along with ...

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