Browsing Research Cell (BUCM-IC) by Title

Now showing items 1-20 of 53

3rd Worldwide Conference on Infectious Diseases Decoding Dengue: A Comprehensive Analysis of Cases at Holy Family Hospital (2019–2023) and Anticipating Pakistan’s Future Dengue Dynamics under Climate Change

Dr. Saira Karimi; Naeem Akhtar, Olodo Katiana; Burhan Ahmad, Mujeeb Khan; Muhammad Umer (Aver Conference, 2023)

This retrospective study considers the comprehensive analysis of dengue fever (DF) cases reported at Holy Family Hospital from 2019 to 2023. Patient data, including demographic features, age, gender, relatedness to DF, ...
Analyzing PKC Gamma (+ 19,506 A/G) polymorphism as a promising genetic marker for HCV‑induced hepatocellular carcinoma

Fizzah Abid, Talha Iqbal, Khushbukhat Khan, Yasmin Badshah, Janeen H Trembley, Naeem Mahmood Ashraf, Maria Shabbir, Tayyaba Afsar, Ali Almajwal and Suhail Razak (Biomarker Research, 2022)

Background: HCC is a major health concern worldwide. PKC gamma, a member of the conventional PKC subclass, is involved in many cancer types, but the protein has received little attention in the context of single ...
Association of 11 variants of the dopaminergic and cognitive pathways genes with major depression, schizophrenia and bipolar disorder in the Pakistani population

Aisha Nasir Hashmi, Merlyn Sabina Raja, Rizwan Taj, Raees Ahmed Dharejo, Zehra Agha, Raheel Qamar & Maleeha Azam (International Journal of Neuroscience, 2023)

Background: The dopaminergic pathways control neural signals that modulate mood and behaviour along and have a vital role in the aetiology of major depression (MDD), schizophrenia (SHZ) and bipolar disorder (BD). Genome-wide ...
Association of dopamine β-hydroxylase polymorphism rs1611115 and serum levels with psychiatric disorders in Pakistani population

Aisha Nasir Hashmi, Raees Ahmed Dharejo, Usama Bin Zubair, Netasha Khan, Iqra Kashif, Muhammad Ajmal, Rizwan Taj, Raheel Qamar & Maleeha Azam (International Journal of Neuroscience, 2022)

Aim: Dopamine β-hydroxylase (DBH) is a copper-containing enzyme that has an important role in maintaining the cellular homeostasis between the two neurotransmitters, dopamine (DA) and nor-adrenaline (NA). DBH functional ...
Association of Monoamine Oxidase A Gene Promoter Region (30 bp μVNTR) Polymorphism with Serum Levels in Multiple Psychiatric Disorders

Aisha Nasir Hashmi 1, Rizwan Taj 2, Zehra Agha 1,3, Raheel Qamar , Jamal B. Williams , and Maleeha Azam (Biomedicines, 2025)

Background: Monoamine oxidase A (MAOA) has a role in metabolising different biogenic amines, including dopamine. Functional studies have revealed the effect of promoter region variants on the transcriptional activity of ...
Bioherbicidal Activity and Metabolic Profiling of Potent Allelopathic Plant Fractions Against Major Weeds of Wheat—Way Forward to Lower the Risk of Synthetic Herbicides

Sobia Anwar, Saadia Naseem; Saira Karimi, Muhammad Rafique Asi; Ahmed Akrem, Zahid Ali (Frontiers in Plant Science, 2021-09-10)

The productivity of major field crops is highly compromised due to weed infestation. Inefficient weed management practices and undue and excessive use of chemical herbicides have drastically contaminated the environment ...
Cloning of Brazzein Gene (Sweet Protein) Into Pbi121 Vector Through Prokaryotic Expression System

B. Saleh, N. Huma; S. Galani (Journal of Animal & Plant Sciences, 2023-06-18)

Brazzein- a low-calorie natural sweetener is an effective substitute for deleterious effects of sucrose. Uptill now, limited production of recombinant brazzein protein using heterologous expression system along with ...
Comparative Biochemical Analysis of High and Low Sucrose Accumulating Sugarcane Varieties at Formative Stage under Heat Stress

Faisal MEHDI, Kazim ALI; Nesheman HUMA, Iqbal HUSSAIN; Abid AZHAR, Saddia GALANI (Journal of Agricultural Sciences, 2019-02-11)

Sugarcane (Saccharum officinarum L) is a valuable cash crop which plays an imperative role in the worldwide economy. However, high temperature has significantly retarded the crop growth and yield by alteration of biochemical ...
Comparison of Ultrasound Therapy and Local Steroid Injection for Treatment of Carpal Tunnel Syndrome using Electrodiagnostics

Omer Jamshed Khan; Naveed Mumtaz; Wafa Munir Ansari (International Journal of Pathology, 2016)

Introduction: To determine the efficacy of ultrasound therapy as compared to intra lesional steroid injection in Carpal Tunnel Syndrome (CTS) using visual analogue scale (VAS) and electrodiagnostic parameters. Study Design: ...
Contributing risk factors of common psychiatric disorders in the Pakistani population

Aisha Nasir Hashmi · Raheel Qamar · Rizwan Taj · Usama Bin Zubair · Zehra Agha · Saddam Akber Abbasi· Maleeha Azam (European Archives of Psychiatry and Clinical Neuroscience, 2023)

With an increasing incidence of psychiatric disorders worldwide, there is a need for a better understanding of the populationspecific contributing risk factors that are associated with common psychiatric conditions. This ...
Decoding Dengue:A Comprehensive Analysis of Cases at Holy Family Hospital (2019-2023) and Anticipating Pakistan's Future Dengue Dynamics under Climate Change

Saira Karimi, Naeem Akhtar; Olodo Katiana, Sajjad Haider; Burhan Ahmed, Mujeeb Khan; Muhammad Umer (Journal of Islamabad Medical and Dental College, 2024-06-25)

Objective: Climate warming and vector born infectious diseases area growing concern under Pakistan's recent climate warming scenario. This retrospective study considersa three-year (2019-2023) comprehensive analysis ...
Diagnostic Accuracy of Serum Prostate Specific Antigen and Gleason Score in Determining the Presence of Skeletal Metastasis in Prostate Cancer Patients : A Pakistani Perspective

Taimoor Nasir; Syeda Neha Aamer; Saman Waqar; Wafa Omer (Journal of Rawalpindi Medical College, 2023)

Objective: To determine the cut-off values for serum Prostate Specific Antigen (PSA) and Gleason score (GS) for predicting bone metastasis of Prostate cancer. Methodology: 330 Prostate cancer patients were enrolled in the ...
Effect of Coronary Artery Disease risk SNPs on serum cytokine levels and cytokine imbalance in Premature Coronary Artery Disease

Wafa M. Ansari; Steve E. Humphries; Abdul K. Naveed; Abdul K. Naveed; Dilshad A. Khan; Ejaz Hassan Khattak (Elsevier (Cytokine), 2017)

Background: Premature Coronary Artery Disease (PCAD) occurs almost a decade earlier in the South Asian population as compared to the West. Inclusion of genetic information can prove to be a robust measure to improve early ...
Evaluation of Gram Stain Error Rates of Clinical Specimens

Rabia Sajjad, Gohar Zaman; Irfan Ali Mirza, Wajid Hussain; Umar Khurshid, Asim Shehzad (2021-03-17)

Objective: To determine important errors in initial Gram staining of clinical specimens and evaluate the types of Gram-stain errors. Study Design: Cross-sectional study. Place and Duration of Study: Microbiology Department, ...
Genetic Analysis Reveals a Missense Mutation in Reactivation Gene-2 (RAG2) Causing Severe Combined Immunodeficiency Disease in a Pakistani Family

Shahida Awais; Lubna Siddique; Nida Shafi; Sobia Humerah; Summyah Niazi; Wafa Omer (Journal of Rawalpindi Medical College, 2024-06-24)

Objective: To perform clinical and genetic analysis in a family suffering from lymphopenia (low B-lymphocyte, T-lymphocyte and healthy Natural Killer cells). Method: In the current research project we enrolled a female ...
Genetic Association of Butyrylcholinesterase with Major Depressive Disorder

Sliha Awan · Aisha N. Hashmi · Rizwan Taj · Sadaf Munir · Rabia Habib · Sajida Batool · Maleeha Azam · Raheel Qamar · Syed M. Nurulain (Biochemical Genetics, 2021)

Major depressive disorder (MDD) is characterized as clinical depression, which primarily affects the mood and behaviour of an individual. In the present study butyrylcholinesterase (BChE), a co-regulatory cholinergic ...
Genetic Diversity of Human Immunodeficiency Virus TypeJ in Asymptomatic Blood Donors in Islamabad, Pakistan

Usman Waheed, Farooq Ahmed Noor; Noore Saba, Akhlaaq Wazeer; Zahida Qasim, Muhammad Arshad; Saira Karimi, Ahmad Farooq; Javaid Usman, Hasan Abbas Zaheer (Journal Lab Physicians, 2020)

Objective The serological testing of human immunodeficiency virus (HIV) is mandatory under the blood safety legislation of Pakistan; hence, data exist on the prevalence of HIV in blood donors. However, little is known ...
Genetic polymorphism in untranslated regions of PRKCZ influences mRNA structure, stability and binding sites

Aneela Mustafa, Maria Shabbir, Yasmin Badshah, Khushbukhat Khan, Fizzah Abid, Janeen H. Trembley, Tayyaba Afsar, Ali Almajwal and Suhail Razak (BMC Cancer, 2024)

Background Variations in untranslated regions (UTR) alter regulatory pathways impacting phenotype, disease onset, and course of disease. Protein kinase C Zeta (PRKCZ), a serine-threonine kinase, is implicated in ...
Genetic Variants at PRKCG Splice and UTR Sites Promote Cancer Susceptibility by Disrupting Epigenetic and miRNA Regulatory Network

Fizzah Abid, Khushbukhat Khan, Naeem Mahmood Ashraf, Yasmin Badshah, Maria Shabbir, Janeen H Trembley, Tayyaba Afsar, Ali Almajwal, Suhail Razak (Journal of Cancer, 2024)

The changes in the protein kinase C gamma gene (PRKCG) expression are associated with both coding and non-coding variants. No studies have specifically established the association between PRKCG 3′UTR, 5′UTR, donor and ...
Guest Editorial: Integrating Special Pathology and Laboratory Medicine into the Transitional Clerkship Model for 4th Year MBBS: A Strategic Educational Realignment

Wafa Omer (2024)

The structure of medical education is critical in shaping competent and well-rounded physicians. In recent years, there has been growing recognition of the need to better integrate basic and clinical sciences throughout ...

Now showing items 1-20 of 53

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