Abstract:
In children, a high level of Lp(a) is a leading risk factor for strokes but strokes are very rare in
any child, even those with a high level of Lp(a). Analysis of the lipid content in the oxidatively
modified LDL from hyper lipidemic patients revealed that the level of
lysophosphatidylcholine was greatly elevated, and the high level of the lysolipid was shown
to impair the endothelium-dependent relaxation of the blood vessels. In alllopathy blood
lipid levels are normalized by statins, fibrates, niacin and bile acid binding resins (BABRs). All
of these allopathy related drugs have low compliance ranges from mild compliance due to
metalic taste of BABRs to severe side effects like rhabdomyolysis by fibrates and statins.
Cardiovascular diseases are leading cause of death in western and eastern countries of the
world. Hyperlipidemia is one of the strong risk fractions for heart diseases. To evaluate
hypolipidemic drugs efficacy, the study was conducted at Ghurki trust teaching hospital,
Lahore Pakistan from January 2018 to August 2018. Ninty hyperlipidemic patients were
selected from cardiology and medical wards of the hospital. They were divided in three
groups, one at placebo therapy, another on Kalonji and third one on Vitamin B3. After one
and half month, significant changes (p value ranging from <0.05 to <0.001) were observed in
their LDL and HDL-cholesterol. Conclusion of the study was to recommend use of herbal
medicine and vitamin B3 for prevention of any heart diseases with good patient
compliance.
