Abstract:
The effects of dietary fats on the risk of coronary artery disease (CAD) have traditionally
been estimated from their effects on LDL cholesterol. Fats, however, also affect HDL
cholesterol, and the ratio of total to HDL cholesterol is a more specific marker of CAD than is
LDL cholesterol. Hypolipidemic drugs and fruits can play a part to reduce LDL particles
decreasing chances of CAD development. This study was conducted to compare
hypolipidemic effects of Niacin and Jujube fruit in primary as well as secondary
hyperlipidemic patients. Study was conducted from November 2018 to February 2019 at
Jinnah Hospital Lahore. Sixty participants were enrolled of both gender male and female
patients age range from 20 to 70 years. Consent was taken from all patients. They were
divided in two groups. Group-I was advised to take 2 grams Niacin in divided doses for the
period of two months. Group-II was advised to take 500 grams of fruit Jujube daily for the
period of two months. Their baseline LDL and HDL cholesterol was determined by
conventional method of measuring Lipid Profile. After two months therapy, their post
treatment lipid profile was measured and mean values with ± SEM were analyzed
biostatistically. Group-I which was on Niacin their LDL cholesterol decreased significantly and
HDL cholesterol was increased significantly. In group-II patients LDL cholesterol was
decreased significantly but HDL increase was not significant with p-value of >0.05. It was
concluded from the research work that Niacin is potent in lowering LDL and increasing HDL
cholesterol, while Jujube has significant effect as LDL cholesterol lowering potential, but it
does not increase HDL cholesterol significantly.
