Abstract:
Thyroid function disorder is a very common disorder among the general population. Almost 3%
of the people around the globe are receiving thyroid replacement therapy around the globe.
Objectives: The study aimed to screen the thyroid function disorder among the women with
recurrent pregnancy loss. The treatment effects of thyroid disorder on the pregnancy
outcomes were also assessed. Methods: This longitudinal study was conducted at Allama Iqbal
Memorial Teaching Hospital Sialkot and Islamic International Medical College, Rawalpindi for
duration of six months from October 2021 to March 2022. The 110 patients were included in the
study to screen abnormal thyroid function and its association with recurrent pregnancy loss. All
patients were fully aware of the study and informed consent was taken. Different screening test
such as free thyroxin (FT ), Thyroid stimulating hormone (TSH), free tri-iodothyronin (FT ) and 4 3
thyroperoxidase antibodies test were performed and data was collected. The thyroxin was given
to the patients with abnormal TSH levels. Results: The free thyroxin (FT ), (TSH), free tri- 4
iodothyronin (FT ) and anti thyroperoxidase level were measured. Out of 110 patients that 3
participated there were 36% in which elevated levels of thyroid stimulating hormone was
observed. Among these 36%, there were 22% that had the level of TSH more than 10 mU/L and
there were 14% patients that had their TSH levels in the range of 7-10 mU/L. These patients were
given thyroxin approximately 26-75 μg per day and the amount of thyroxin was adjusted
according to the level of Thyroid stimulating hormone. Out of these 36% women that had high
levels of TSH, there were 21 women that conceived within 1 year of treatment. Among the 33%
women with high level of TSH, there were 39 that underwent the anti TPO test. Conclusion:
Women who face recurrent pregnancy loss should be checked for thyroid abnormality as it was
detected that there is signicant number of women who face hypothyroidism and recurrent
pregnancy loss.
