Abstract:
Background: As a repercussion of oxidative stress, reactive oxygen species augment the bio
chemical reaction of amino and carbohydrate groups of proteins, thus forming oxidative products known as Advanced Glycation End-products (AGEs), associated with acute coronary syndrome (ACS). Together, this milieu provokes oxidative stress and promotes the development of
ACS.
Methods: The studied cohort had 76 ACS individuals and 76 healthy controls. Blood samples of both groups were collected to measure the concentration of AGEs, Malondialdehyde
(MDA), and the activity of antioxidants. Levels of lipid profile and inflammatory biomarkers were
accessed in the study. The spectrophotometric ELISA kit was used to determine the levels of
parameters.
Result:TheresultsindicatedasignificantincreaseinAGEs,MDA,LDL,andtotalcholesterollevels.
Increased inflammatory markers, Intercellular adhesion molecule 1, and vascular cell adhesion
proteins-1 in ACS patients were compared with the control subjects. A decrease is recorded in
superoxide dismutase, HDL, and glutathione levels in ACS individuals.
Conclusion: Our study demonstrated increased serum concentration of AGEs and several other
factors, such as increased oxidative markers and, conversely, reduction in the antioxidant in
ACS individuals. Therefore, we conclude these variables can be a potential biomarker in ACS
individuals.
