To Evaluate the Inter-Relationship of Pro Inflammatory Tnf-Α, Il-6 And C-Reactive Protein and Nitric Oxide with the Formation of Radicular Cyst

Abstract

Background: Granulomas and radicular cysts are taken as the stages of development of inflammatory. Increased level of TNF-α is observed in inflammatory exudates from radicular cyst and plays an important role in pathogenesis. Objectives: Study was designed to evaluate the inter-relationship of pro-inflammatory IL-6, TNF-α, C-reactive protein and nitric oxide with the formation of radicular cyst. Methods: Seventy patients with age range 20-40 years who visited Department of Dentistry of University of Lahore during the period of September 2014 -November 2014. These patients were included in the study. Subject under study were comprised as group A and group B: Group A was included 20 individuals with healthy attached gingival with probing depth of less than 3mm. Group B was included 50 patients with radicular cysts selected with the criteria of clinical attachment loss of greater than 3mm. Results: Levels of biochemical variables were evaluated in suffering with radicular cyst. It is observed that the level of IL-6, TNF-α and of Nitric oxide was significantly increased in subjects as compared to the values of these variables of control or normal subjects. However the level of CRP was slightly increased in patients as compared to controls. Conclusion: Pro-inflammatory markers including serum IL-6, TNF-α and nitric oxide may have a role in the formation of radicular cyst. However, there was no role of serum C-reactive protein in the formation of radicular cyst.