Uterine Leiomyoma in Relation to Insulin like Growth Factor-1

Abstract

Background: Uterine leiomyoma is a very common benign smooth muscle tumor of the uterus. It isthe most frequent benign neoplasm in women of reproductive age and could have a harmful impact on the reproductive system. Insulin-like growth factor–I (IGF-I) plays a vital role in the pathogenesis of fibroids. Aim: To find out the relationship of uterine leiomyoma with insulin like growth factor -1. Study design: Cross sectional study Methods: A Cross Sectional study for duration of 6 months (May 2013- Nov 2013) was designed. 50 women with uterine fibroids (confirmed by USG) with age range of 25-50 years with confirmed report of fibroid USG, were included in the study. A group of 50 women with no history of disease were taken as controls. Level of plasma IGF-1 was measured by ELISA. Results: About 44% cases and 11% controls had irregular menstrual cycle. An average of two fibroids was noted. About 54% women have small size fibroid (<2cm) and 46% have large size fibroid. Intramural fibroid was observed in 78% and subserosal in 22%. Level of plasma IGF-1 was significantly increased in patients as compared to controls. Conclusion: It is concluded that there is a direct relationship of uterine leiomyomata with IGF-1. However, more research is needed to find out the association of IGF-1with the onset of myoma and its growth.