Clinicopathological Features of Hodgkin Lymphoma in Patients of Peshawar Region

Abstract

Aim: To study the age incidence, common pathohistologic subtypes, and clinical presentation of patients with Hodgkin lymphoma (HL) in local population. Materials and Methods: This retrospective study was carried out by reviewing medical record for all lymph nodes biopsies with the diagnosis of HL in Rehman Medical Institute Peshawar from year July 2011 to Jan 2018 Results: Total of 31 lymph node biopsies were examined. Twenty nine (94%) cases were diagnosed with Classical Hodgkin lymphoma (CHL) and only 2(6%) were diagnosed with nodular lymphocyte predominant (NLPHL) type. Among all our cases 65% were males and 35% were females and mean age of presentation was 28.42 years. The major site of lymph node involvement from where biopsy was taken for histological diagnosis was found to be the cervical group of lymph nodes involving 58% of the cases. Histological subtyping of the cases in the study indicates that mixed cellularity HL constitute 22 cases (76%) making it the most predominant subtype followed by nodular sclerosis 7 cases (24%). Conclusion: Patients are predominantly males and the most common presentation was cervical lymphadenopathy. Major bulk of the patients with Hodgkin lymphoma suffer from classical Hodgkin’s lymphoma and the most dominant subtype was mixed cellularity Hodgkin’s lymphoma.