Abstract:
Objective: To explore the role of dyslipidemia in
development of thyroid disorder in type two diabetes
mellitus.
Methodology: In this randomized control trial, 60
Sprague Dawley rats were divided into two groups
with 30 rats in each group. Group 1 (control group)
was fed on normal pellet diet and water whereas group
two (diabetic group) was fed high fat diet to produce
insulin resistance. After 2 weeks, an intra-peritoneal
injection of normal saline was given to all the rats in
group 1, and group 2 rats were given single intra
peritoneal injection of Streptozocin (35 mg/kg) to
produce hyperglycemia. At the end of study period (8
weeks), serum lipid profile, triiodothyronine, thyroxine
and thyroid stimulating hormone levels were
measured. Pearson correlation coefficient was
calculated to find correlation between lipid profile and
thyroid profile.
Results: There was no significant correlation of
thyroid stimulating hormone, triiodothyronine and
thyroxine with the parameters of lipid profile.
Conclusion: The deranged lipid profile had no role in
disturbing the thyroid hormone levels in STZ induced
type 2 diabetic Sprague Dawley rats.
