Abstract:
Introduction: To study the protective effect of extra virgin olive oil (EVOO) on histopathological
changes induced by arsenic in the kidneys of albino rats. Randomized control trial. November 1,
2017–November 30, 2017 at National Institute of Health. Material and Methods: Forty-five male
adult albino rats were placed in three cages having 15 rats each. Distilled water was given to the
rats of control Group I for 30 days. The dose of sodium arsenite given to rats was 40 mg per kg per
day dissolved in drinking water for 30 days. Olive oil of 0.2 ml per day was only given to Group III
rats for 30 days along with sodium arsenite. In dissection was done after 30 days and their kidneys
were approached and dissected out for histological changes. Results: EVOO has ameliorated the
microscopic quantitative and qualitative histological changes induced by arsenic on both kidneys
of albino rats. Olive oil had significantly prevented the increase in the diameter of the proximal
convoluted tubule (PCT). Discussion and Conclusion: The present study demonstrates that EVOO
prevents the quantitative and qualitative histological changes caused by arsenic on kidneys which
include the diameter of PCT and distal convoluted tubule, the diameter of glomeruli, width of
bowman’s space, and loss of brush border.
