Green Tea Offers More Nephroprotection than Cinnamon against Bisphenol an Induced Tubular Damage in Rat Kidney: A Histological Quantitative Approach

Abstract

Objective: To compare protective efficacy of cinnamon extract and green tea against Bisphenol A induced histological changes in rat kidney. Study Design: Randomized control trial study Place and Duration of Study: This study was conducted at the Department of Anatomy, Islamic International Medical College, and National Institute of Health, Islamabad from September 2016 to September 2017. Materials and Methods: Sixty adult male Sprague Dawley rats were divided into four groups with 15 rats in each group. Control group A rats were given distilled water for 30 days subcutaneously. Experimental group B rats were administered Bisphenol A at a dose of 30mg/kg/day subcutaneously for 30 days. Experimental group C rats were given cinnamon at a dose of 200mg/kg/day orally along with subcutaneous Bisphenol A injection. Experimental group D rats were given green tea orally along with subcutaneous Bisphenol A injections. After dissection right kidneys of all rats were examined for histological changes. Results: The histological parameters of rat kidneys were observed under light microscope. These included height of epithelium of PCT, luminal diameter of PCT, height of epithelium of DCT and luminal diameter of DCT. Worsening of these parameters from control group was maximally seen in group B. However, both groups C and D caused improvement in all measured histological parameters but group D displayed more nephroprotection than group C. Conclusion: The oxidative stress caused by Bisphenol A has adversely affected kidneys and green tea was found to be more beneficial in ameliorating nephrotoxic effects of Bisphenol A than cinnamon.