The Ameliorative Effect of Ginger on Cadmium Induced Histological Changes in Testes of Albino Rats

Abstract

Objective: To study the ameliorative effect of ginger against histological changes induced by cadmium in testes of albino rats. Study Design: Randomized control trial. Place and Duration of Study: The research was conducted at animal house, National Institute of Health (NIH), st Islamabad. The research was carried out for one year of duration from 1 November 2017 to 28 November 2018. Material and Methods: Forty-five male adult albino rats were included via simple random sampling technique. Using balloting method, each subject was randomly allocated into one of the three groups. Distilled water was orally given to rats of control group I. The rats of group II were provided with cadmium chloride while group III received cadmium as well as ginger in selected doses orally for 28 days. Dissection was done after 28 days and testes were observed for histological changes. Results: The use of ginger ameliorates the gross and microscopic changes induced by cadmium in testes of Albino rats of group III as compared to group II rats, which received only cadmium. Among microscopic qualitative parameters, infiltration, congestion and necrosis were markedly reduced by use of ginger in group III rats. Conclusion: The use of ginger improves the histological changes induced by cadmium in testes of albino rats.