Abstract:
Objective: To study the ameliorative effect of ginger against histological changes induced by cadmium in testes
of albino rats.
Study Design: Randomized control trial.
Place and Duration of Study: The research was conducted at animal house, National Institute of Health (NIH),
st
Islamabad. The research was carried out for one year of duration from 1 November 2017 to 28 November
2018.
Material and Methods: Forty-five male adult albino rats were included via simple random sampling technique.
Using balloting method, each subject was randomly allocated into one of the three groups. Distilled water was
orally given to rats of control group I. The rats of group II were provided with cadmium chloride while group III
received cadmium as well as ginger in selected doses orally for 28 days. Dissection was done after 28 days and
testes were observed for histological changes.
Results: The use of ginger ameliorates the gross and microscopic changes induced by cadmium in testes of
Albino rats of group III as compared to group II rats, which received only cadmium. Among microscopic
qualitative parameters, infiltration, congestion and necrosis were markedly reduced by use of ginger in group III
rats.
Conclusion: The use of ginger improves the histological changes induced by cadmium in testes of albino rats.
