Lipoprotein abnormalities in diabetic patients

Abstract

Objectives: To evaluate and compare blood glucose levels and lipid profile in diabetic vs healthy adults. Methodology: This descriptive cross sectional study was conducted from January 2021 to April 2021. The study samples were collected from Northwest General Hospital Peshawar. Sixty patients with diagnosed type 2 diabetes and an equal number of control subjects were included in this study. After the recruitment of subjects according to the inclusion criteria, subjects were divided into two cohorts; Patients with Diabetes (Group I N=60) and a Non-Diabetic Control Group (Control group N=60). Blood from the subjects was checked for glucose levels and lipid profile. Blood was taken and analysed at the Hospital Lab via Cobas 6000 analyser. Data was analysed using SPSS version 26.0 for MacBook Pro. T test was applied to the data and p value was kept at <0.05 for significance. Results: Fasting Blood Glucose (FBS) rise was statistically significant (p=0.03) with a mean and standard deviation (SD) of 161.21±46.31* for Group I and 79.29±18.56 for Group II with a Mean Difference (MD) of 81.92. Triglycerides (TGs) rise was statistically significant (p=0.03) with a mean and SD of 197.29±68.56* for Group I and 141.16±42.63 for Group II with a MD of 56.13. High Density Lipoprotein (HDL) were decreased significantly (p=0.01) in the Group I (30.08±3.02*) in comparison with Group II (45.1±4.98) with a MD of 5. Conclusions: In conclusion, our study results show that diabetic patients have lipoprotein derangements. However, further studies are required for not only understanding the medical condition but also to establish a possible link of developing cardiometabolic syndrome and cardiovascular diseases.