Abstract:
Background: To determine the possible correlation between raised serum
uric acid and various components of metabolic syndrome (Waist circumference, serum
triglyceride, plasma HDL-C). Study Design: Descriptive case control. Setting: Army Medical
College laboratory, Military Hospital, Rawalpindi. Period: One year (November 2014 to October
2015). Material and Methods: Total of 100 subjects were enrolled in this study. WHO criteria
were applied for identifying the patients of metabolic syndrome. Fasting plasma glucose,
lipid profile and serum uric acid levels were measured by using colorimetric enzymatic
method. The formula of Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) was
applied to calculate Insulin resistance. Collected data was analyzed by using SPSS- Window
version-17 for statistical analysis. Results: Serum uric acid levels were turned out to be high in
metabolic syndrome patients (cases= 6.1±1.3mg/dL) when compared with controls (having
no symptoms of MetS=3.6±1.2; p<0.001). Uric acid showed a statistically significant positive
association with waist circumference (WC=r-value:0.250; p-value:0.000) and serum triglyceride
(TG=r-value:0.341; p-value:0.000). Negative correlation had been found between plasma
high-density lipoprotein-cholesterol (HDL-C=r-value: -0.173; p-value:<0.01) with uric acid
levels. Conclusion: Serum uric acid levels show a significant association with components
of metabolic syndrome making it a powerful biomarker of metabolic syndrome and its various
cardiometabolic complications.
