Abstract:
Background: The updated guidelines by CDC (center for disease control) narrated the importance
of using the dataprovided by hospital antibiogram for initial prescription of managing the infections.
Therefore the current study had been planned to formulate the antibiogram in a tertiary care
hospital of Islamabad.
Objectives: To identify the local antibiotic susceptibility pattern against various isolates of urine
pathogens. Materials and Methods: A descriptive cross sectional study was conducted at the Pathology
department of Al Nafees Medical College & Hospital, Islamabad, Pakistan. The duration of study
was 04 months i.e between1st June to 1st Oct. 2015. Total 336 suspected urinary tract infection,
urine specimens (indoor and outdoor) received for culture and sensitivity were included in the
study. Recommended clean catch method was advised for urine sample collection. The specimen
processing was done by following the three days recommended protocols for urine cultures by
Clinical and laboratory standard institutes (CLSI).Frequencies and percentages were the numerical
variables extracted by using the SPSS version 16.
Results: Out of total 336 samples, 9.8% (n=33) urine cultures were positive. Escherichia coli (E.
coli) was present in (60.6%), Klebsiella pneumoniae in (12.1%), Pseudomonas aeruginosa in
(9.09%), Proteus mirabilis in (6.06%), Morganella morganii in (6.06%) and Staphylococcus
saprophyticus in (6.06%). The drugs of choice for E. coli are quinolones and aminoglycosides by
showing the sensitivity of about (75%) each. For Klebsiella pneumoniae, the ideal antibiotics are
aminoglycosides (85.1%) and 2nd generation cephalosporins (85%). For Pseudomonas
aeruginosa, extended spectrum penicillin, quinolones, 2nd and 3rd generation cephalosporins are
the most suitable ones showing the sensitivity of (100%) each.
Conclusion: Quinolones, aminoglycosides, 2nd and 3rd generation cephalosporins are the drugs of
choices for the treatment of urine infections.
