Anti-Microbial Susceptibility Pattern of Linezolid in Various Clinical Isolates

Abstract

The literature review is suggestive of good efficacy of Linezolid (Oxazolinedione derivative) against gram positive bacteria only. However it is deficient regarding its susceptibility in various clinical isolates. Therefore, the current study was planned to identify the susceptibility pattern of Linezolid in various isolates. Total 748(n) specimens were included in this study. Out of which 144(n) yielded positive growth. For microbiological culture proceedings all recommended CLSI – 2014 (Clinical and laboratory standard institute) guidelines were followed. The linezolid having 30μgm disc potency was used to assess its susceptibility. The clearing zone diameter of >21mm was considered sensitive. Data was recorded and analyzed by using SPSS version 20 for statistical inference. For numerical variables, frequencies were calculated in terms of percentages. The results of current study showed that 84.2% gram-positive and 45.6% gram-negative organisms were sensitive to linezolid. The efficacy of linezolid is more for gram-positive i.e 84.2% as compared to gram-negative 45.6%.