Abstract:
OBJECTIVES: The aims and objectives of the study were to identify the patients with hereditary predisposition for thromboembolism and to assess the distribution of natural anticoagulants deficient in such patients.
METHODS: It was a descriptive cross sectional study. A screening test ProC Global was carried out to detect deficiency of protein C or S and then susceptibility of protein C and protein S assays were carried out on the positive cases. The level of antithrombin and the screening test for factor V Leiden were carried out separately.
RESULTS: A total of 264 patients were referred for ProC Global out of which 25 (39.0 %) were positive. The protein C was deficient in 3 patients detected by protein C assay and no patient was deficient in protein S. Antithrombin deficiency was detected in 16 out of 190 (8.4 %) patients and screening test for factor V Leiden was positive in three out of 30 (10 %) cases.
CONCLUSION: Inherited thrombophilia is common in patients having a positive history of arterial or venous thrombosis.
