Hospital Antibiogram: A Necessity in Monitoring Sensitivity of Isolates and Rationale Use of Antibiotics

Abstract

Background: The laid protocols by CDC (center for disease control) narrated the dire need of local anti-biograms. Therefore the current study had been planned to acquire the knowledge about sensitivity pattern of various isolates in different specimens. Objectives: To identify the local antibiotic sensitivity data against various isolates from different specimens. Materials and Methods: A descriptive cross sectional study was conducted at the Pathology department of Al Nafees Medical College & Hospital, Islamabad, Pakistan. The duration of study was 04 months i.e 01st June to 01st Oct. 2015. Frequencies and percentages were the numerical variables extracted by using the SPSS version 16. Results: A total of 336 different specimens were received during study period. E. coli is commonest organism isolated from urine, high vaginal swabs (HVS) and Pus i.e. 60.60%, 100% and 25% respectively. Klebsiella species is the second most common organism (12.12%) followed by Pseudomonas (9.09%) isolated from urine. E. coli, Klebsiella, Pseudomonas and Staphylococcus aureus were isolated at same frequency (25%) from pus. Salmonella typhi was isolated from blood (100%). The drugs of choice for E. coli are quinolones and aminoglycosides by showing the sensitivity of about 75% each. For Klebsiella pneumoniae, the ideal antibiotics are aminoglycosides (85.1%) and 2nd generation cephalosporins (85%). For Pseudomonas aeruginosa, extended spectrum penicillin, quinolones, 2nd and 3rd generation cephalosporins are the most suitable ones showing the sensitivity of 100% each. Conclusion: Quinolones, aminoglycosides, 2nd and 3rd generation cephalosporins are the drugs of choices for the treatment of many gram positive and gram negative infections.