Meta-analysis for Searching Efficacy of Tinidazole and Metronidazole

Abstract

Background: The 5-nitroimidazole antimicrobial agents are considered as the treatment of choice for managing the amebic, protozoal and anerobic infections since 1969. With the advancement in medical field certain preference of drugs in this group were given. Tinidazole is now considered as a better one as compared to metronidazole because of specific pharmacokinetic & pharmacodynamics properties. Objectives: To assess the frequency of preferred using tinidazole as compared to metronidazole for managing the amebic, protozoal infections and anerobic infections Methodology: This is a descriptive study with simple random sampling. Total 32 published studies in 04 decades were included in the study i.e 1978 – 2017. The National and Internationally published data was gathered by using electronic measures and via certain search engines i.e pubmed researches, medscape, Pak medinet.com, google search, Euraopean, Canadian, Australlian, Centre for Disease Control (CDC), and World Health Organization (WHO) published guidelines. The published guidelines, original and review articles were taken for reference. Case reports, editorials & short communications were excluded. Results: This Meta-analysis review of various published researches showed that out of 69.2%(n=09) out of total 13 studies are in favour of preferring tinidazole. The frequency preference of metronidazole is 23% (n=23). Only one study (7%) showed the efficacy of both drugs is same. Conclusion: Tinidazole is a better option to manage anaerobic, amebic and protozoal infections.