Comparative Efficacy of Tocotrienol and Tocopherol for their Anti Diabetic Effects

Abstract

Background: Diabetes is a chronic metabolic disorder and a Global health problem. Lifestyle modifications along with addition of miro nutrients and vitamin supplementation can be helpful to delay the occurrence of its life-threatening complications. Therefore, this systematic review was carried out to identify the comparative role of tocotrienol and tocopherol isoforms of antioxidant vitamin E for diabetic patient management. Research Question: Is tocotreinol has better anti diabetic effects as compared to tocopherol? Methodology: This systematic review was carried out following the PRISMA protocol and guidelines. Initially 86(n) articles were included which were than sort out to finally include 05(n). This was done following the pre defined inclusion and exclusion criteria of systematic review. Results: The results strongly supported the inclusion of tocotrienol as part of therapeutic management of diabetes mellitus. The dose can range from 200mg to 430 mg. However, no data was available to identify comparative efficacy of tocopherol. Conclusion: Tocotreinol because of its antioxidant, anti-inflammatory and anti fibrolytic properties helps marinating the glycemic levels in diabetic patients. Besides this the emergence of diabetic complications was delayed. A clinical improvement in patients with diabetic nephropathy and neuropathy was seen as well. It was also observed that grape seed oil supplement of tocotrienol was proven beneficial as compared to sunflower oil supplement especially by lowering inflammatory markers.