Comparative Efficacy of Various Diagnostic Modalities for Confirming Acute Dengue Viral Infection Against 04 Serotypes

Abstract

Background & Introduction: Dengue viral infection is a Global health problem. In the absence of vaccine and anti-viral, early diagnosis and management harbors great significant. Therefore the current systematic review was planned to identify the most accurate diagnostic modality for acute infection. Objective: To compare the efficacy of various lab diagnostic tests for confirming acute dengue viral infection against 04 serotypes. Methodology: This systematic review was carried out by following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Final sample size was 07 (N). However it was extracted by narrowing down 24 (n) studies by four steps i.e identification, screening, eligibility and inclusion criteria. Latest published researches form last five years were included by using various search engines e.g Pubmed, Pakmedinet, Cochrane data base, Google scholar and open google search. Results: Out of 07(N) studies, three (n=04) strongly supported that diagnostic efficacy was highest for RT – PCR followed by NS1 Ag ELISA and than IgM ELISA. One (n=01) study emphasized single-tag hybridization-printed array strip (STH-PAS), a most accurate rapid diagnostic test. In one more study rapid diagnostic test (RDTs) was correlated with the economical burden for surveillance system. Conclusion: It is concluded that diagnostic accuracy from highest to lowest is for RTPCR > NS1 ELISA>IgM ELISA