Abstract:
The Botulinum toxin or Botox is virulent factor produced by Clostridium
botulinum. It belongs to a group of Gram positive spore forming rods.
Botulinum toxin is a neurotoxin which is inhibiting the release of
acetylcholine at neuromuscular junction. The resultant effect is paralysis
of specific group of muscles. This Botulinum toxin comprises of seven
neurotoxins. Amongst all of them toxin type A and B harbors clinical
significance especially in the field of medicine, surgery, and dermatology.
The optimum dose ranges from 15 – 20 units. The effect starts within 24
hours to two weeks and last until 3 to 6 months. However published data
was limited to assess its efficacy in various conditions. Therefore this review
article was planned to get the insight regarding clinical efficacy and side
effects of botox for various disorders. The results extracted from the review
of literature showed that it is safe with minimum side effects to treat many
medical and surgical conditions.
Conclusion: Usage of Botox is safe for the management of various medicines,
surgery disorders. The good results can be seen even used for cosmetic
purpose. Careful approach should be opted for immunosuppressed
patients due to serious side effects.
