Antimicrobial susceptibility patterns among community and health care acquired carbapenem resistant Enterobacteriaceae, in a tertiary care hospital of Lahore

Abstract

Objective: To compare the disk susceptibility pattern of healthcare-acquired carbapenem-resistant Enterobacteriaceae with that of community-acquired isolates and their associated clinical presentations Methods: The cross-sectional study was conducted at the Department of Microbiology, Combined Military Hospital, and the Institute of Dentistry, Lahore, Pakistan, from November 2017 to July 2018. Patients with positive carbapenem-resistant Enterobacteriaceae cultures from clinical specimens were included. All the isolates were identified through conventional methods and standard biochemical tests. Antibiotic susceptibility testing was performed by Kirby Bauer Disk Diffusion method on Muller Hinton Agar plates. Data was analyzed using SPSS Provisionally Accepted for Publication Result: Of the 123 isolates identified, 97(79%) were healthcare-acquired and (21%) were community-acquired. Statistically significant susceptibility patterns (p<0.001) of community-acquired isolates were observed against cefopera zone-sulbactum and amikacin, while a low significance was observed with gentamycin (p<0.05). Significant results were obtained in the case of colistin against both groups (p<0.001).Conclusion: There was low antimicrobial resistance in community-acquired carbapenem-resistant Enterobacteriaceae isolates.