Abstract:
Objective: To investigate the association between prostate volume and estrogen levels in obese and non-obese individuals
suffering from Benign Prostatic Hyperplasia (BPH).
Study Design and Setting: Cross-sectional, analytical study
Methodology: The International Prostatic Symptom Score (IPSS) was used in the study to recognize sixty participants with
BPH. The study examined patients' height, weight, waist circumference (WC), and body mass index (BMI). An IPSS score
of less than 7 was seen as healthy. Using standardized BMI (25) and waist circumference (90cm), patients were split into
two groups, with obese patients being placed in group A and non-obese patients being placed in group B. Using trans-rectal
ultrasonography(TRUS), prostate gland's dimensions were measured, and blood samples were taken to determine serum
estrogen levels.
Results: In comparison to the non-obesity group, which had a mean prostate volume (PV) of 31.21±6.771 ml, the obese
group's PV was 36.13±3.673ml. It was statistically significant that there was a difference between the two groups (p=0.001).
In the non-obese group, average level of estrogen was 309.72±73.62pmol/l, compared to 328.21±115.05pmol/l in the obese
group (p=0.462). Correlation study (r=0.279,p=0.031) revealed a significantly ideal relationship between participants' blood
estrogen levels and PV. Among patients who were obese, there was a significant positive correlation among blood estrogen
levels and prostate size(r=0.638, p=0.0001).
Conclusion: When compared to the non-obese group, obesity significantly raises prostate volume in study participants,
leading to benign prostatic hypertrophy. In addition, prostate volume and blood estrogen levels in obese males showed a
significant positive association
