Abstract:
Objective: The objective of this study is to compare the sensitivity and specificity of the SOFA (Sequential Organ Failure
Assessment) and qSOFA (Quick Sequential Organ Failure Assessment) in predicting infection and mortality in ICU (intensive
care unit) and HDU (high dependency unit) patients admitted at a tertiary care center of excellence.
Study Design and Setting: Prospective observational non-interventional study. Anesthesia Department of Combined
Military Hospital, Rawalpindi from Jan 2023-Jun 2023.
Methodology: Patients in both ICU (n=220) and HDU (n=220) setups admitted with a suspicion of sepsis were evaluated
for onset of sepsis and mortality. Primary variables studied were the sensitivity and specificity for both scores for predicting
infection and mortality in the ICU and HDU. Positive predictive value for both scores were calculated as secondary variable.
Results: While assessing the primary variables, the sensitivity of SOFA for predicting infection in the ICU was 25.6% with
a specificity of 85.3% versus a sensitivity of 76.8% and specificity of 59.0% for qSOFA. In the HDU, It showed sensitivity
and specificity with PPV for SOFA being 64.7%, 95.1% and 64.7% versus 79.3%, 85.3% and 46.9% for qSOFA respectively.
While assessing for mortality, SOFA values in the ICU for sensitivity, specificity and PPV were 81.8%, 93.5% and 69.2%
versus 88.8%, 58.3% and 90.9% for qSOFA respectively.
Conclusion: We conclude that qSOFA to be good predictor of mortality in the HDU and SOFA with good specificity for
infection and mortality in the ICU
