STUDY THE ASSOCIATION OF VARICOSE VEIN WITH INFLAMMATORY BIOMARKERS

Abstract

The increase in the prevalence of the varicose vein has opened the gates for further research and exploration on this particular topic. The association between varicose veins and increased levels of inflammatory biomarkers has been studied previously, but no study has been done yet to assess the correlation between the changes occurring in the concentration of the inflammatory biomarkers in the blood and the changes occurring in the diameter of the varicose veins. To find out this correlation, patients suffering from varicose veins were recruited who fulfilled the inclusion criteria set for this study. This was a case-control study and consisted of 76 participants (38 cases, 38 controls). Doppler ultrasound was used to measure the changes that have occurred in the walls of the abnormally dilated veins. Blood samples from the abnormally dilated superficial veins in lower limb of each patient were collected to analyze the concentration of inflammatory biomarkers i.e., fibrinogen. The results obtained were analyzed statistically to determine any significant correlation. It was observed that fibrinogen levels were significantly elevated in patients suffering from varicose veins and ulceration, and this increase was significantly correlated with the changes in the diameter of the wall of the varicose veins (p= .000). The occurrence of the varicose vein among the different ethnicities of the country was also found to be statistically significant (p= .005). It can be concluded that fibrinogen can be used as a biomarker to monitor the severity and prognosis of this disease and can also be used to determine the efficacy of the management given to the patients who suffer from varicose vein