Beyond the Digestive System: Understanding Gut-Brain-Microbiome Axis in Irritable Bowel Syndrome

Abstract

IBS affects a significant number of people worldwide, particularly those under the age of 50, with women being twice as likely to be affected than men. Although the underlying pathophysiology of IBS is not yet fully comprehended, current research indicates that it could be related to the Gut-Brain Axis (GBA). This communication is vital to the intricate balance of the gastrointestinal system. Through this axis intestinal motility, secretion, and sensation are harmoniously regulated, resulting in efficient digestion and optimal nutrient absorption. Disturbance in the Gut-Brain Axis is linked to a broad spectrum of psychiatric and gastrointestinal disorders, including IBS. Managing IBS effectively requires a multidisciplinary approach, including dietary modifications, stress management techniques, medications, and psychological therapies. Proper management of IBS can lead to a healthy and fulfilling life for individuals affected by the disorder. Further studies are required to clarify the causes and development of most effective treatments for IBS.