Abstract:
Objective: To determine the association of Metabolic Disorders in women of reproductive age with polycystic ovarian
syndrome (PCOS)
Study Design and setting: Cross Sectional Study conducted in the Department of Gynecology and Obstetrics, Ward 9,
Jinnah Postgraduate Medical Center, Karachi.
Methodology: The study was conducted from November 2021 to February 2022. A total of 227 diagnosed patients of
PCOS were included in this study. Five components of Metabolic syndrome were assessed: Body Mass Index (BMI), blood
pressure, central obesity, fasting blood sugar and lipid profile. Informed consent was obtained from all participants. Patients’
history, physical examination and laboratory investigations in terms of symptoms and findings relating to MS were recorded
and assessed using SPSS version 21. Descriptive statistics were calculated and stratification was done. Chi-square test used
post stratification and p-value =0.05 were considered significant.
Results: Mean age was 27.05±4.51 years. Mean symptom duration was 11.26±3.02 months. Central obesity, hypertension,
hypertriglyceridemia, HDL-cholesterol <50 mg/dl and fasting glucose >100 mg/dl were found in 44.9%, 31.7%, 38.3%,
27.3%, and 38.8% patients, respectively. A total of 47 (20.7%) study subjects were identified with two or more above
components of MS. Significant association of MS with age (>27 years; p<0.000) and duration of disease (>12 months;
p<0.000) was observed.
Conclusion: A higher prevalence of MS was observed when participants aged more than 27 years and had symptoms for
more than a year. Higher BMI was also found nearing statistical significance.
