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dc.contributor.author | Sanum Ali | |
dc.contributor.author | Shahid Rasul | |
dc.contributor.author | Surrendar Dawani | |
dc.contributor.author | Sarah Zahid | |
dc.contributor.author | Sehrish Hussain | |
dc.contributor.author | Ovais Sarwar | |
dc.contributor.author | Tanweer Fatima | |
dc.contributor.author | Zainab Tariq | |
dc.date.accessioned | 2022-04-21T05:11:52Z | |
dc.date.available | 2022-04-21T05:11:52Z | |
dc.date.issued | 2022-04-01 | |
dc.identifier.issn | 2220-7562 | |
dc.identifier.uri | http://hdl.handle.net/123456789/12700 | |
dc.description.abstract | Objective: To compare the effect of chemical composition of cholesterol and pigment stones on gallbladder mucosa. Study design & setting: This comparative cross-sectional study was conducted in the Department of Anatomy, BMSI, JPMC, Karachi, Pakistan, from April to September 2021. Methodology: Total n= 120 gallbladder specimens were collected after cholecystectomies in 10% formalin. Gross morphological features of gallbladder and stones were observed. Specimens were processed and 5µm sections from fundus, body & neck of gallbladder were stained and examined for microscopic changes. Chemical analysis of stones was carried out to differentiate between cholesterol & pigment stones. Results: We evaluated different histomorphological alterations in gallbladder with reference to both type of gallstones. Muscular wall thickness in pigment stone group was noted to be (143.89±78.66) and in cholesterol group (158.37±83.95). Both pigment and cholesterol stone showed increased tendency of muscular hypertrophy. Mucosal ulceration, chronic inflammatory cell infiltration, capillary congestion and hyperplasia (p-value: 0.04) were observed in both type of stones. Statistical analysis showed that large cholesterol stones produce significant histopathological changes (p-value: 0.004); greater the size of stone, more profound was the mucosal hyperplasia. Rokitansky-Ashcoff sinuses were predominant in gallbladders with cholesterol stone. Conclusion: Gallstones cause series of histopathological changes ranging from chronic cholecystitis to pre-malignant and malignant changes. Hyperplasia was observed to be more frequent with long standing, large cholesterol stones. | en_US |
dc.description.sponsorship | JBUMDC | en_US |
dc.language.iso | en | en_US |
dc.publisher | Bahria University Medical and Dental College Karachi | en_US |
dc.relation.ispartofseries | 12;02 | |
dc.subject | Cholelithiasis, Gallstones, Gallstone disease, Hyperplasia. | en_US |
dc.title | Effects of Chemical Composition of Cholesterol and Pigment Stones on the Gallbladder Mucosa | en_US |
dc.type | Article | en_US |